Protein Modification Reagents
Medchemexpress LLC DBCO-PEG24-acid | 2765066-36-0 | C70H116N2O28 | 5 MG
DBCO-PEG24-acid is a click chemistry reagent and an analog of DBCO-Acid featuring a PEG linker and a DBCO group. The DBCO group is utilized in copper-free Click Chemistry reactions due to its strain-promoted high energy. The hydrophilic PEG chain enhances water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g., EDC or HATU) to form a stable amide bond. This product is reagent grade and intended for research use only.
- Click chemistry reagent
- Analog of DBCO-Acid with PEG linker and DBCO group
- DBCO group for copper-free Click Chemistry reactions
- Strain-promoted high energy DBCO group
- Hydrophilic PEG chain enhances water solubility
- Terminal carboxylic acid reacts with primary amine groups
- Forms stable amide bond with activators (e.g., EDC or HATU)
- Reagent grade
- Intended for research use only
Medchemexpress LLC Azide-PEG-amine (MW 5000) | 95.0% | N₃(CH₂CH₂O)nNH₂ | 50 MG
Azide-PEG-amine (MW 5000) is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group. This allows it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs utilize the ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Facilitates protein degradation via PROTACs
- White to off-white solid appearance
- Average molecular weight of 5000
Creative Pegworks mPEG-OH, MW 2k | 9004-74-4 | MFCD00084416 | 50g
mPEG-OH, MW 2k | 9004-74-4 | MFCD00084416 | 50g
Medchemexpress LLC Mal-PEG4-bis-PEG4-propargyl | 1060.19 | C49H81N5O20 | 10 MG
Mal-PEG4-bis-PEG4-propargyl is a polyethylene glycol (PEG) based, cleavable linker designed for bioconjugation and antibody-drug conjugate (ADC) assembly. It features a thiol-reactive maleimide and an alkyne (propargyl) handle to enable both thiol conjugation and copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry, providing flexibility for payload attachment and linker assembly.
- Cleavable 8-unit PEG spacer for improved solubility and flexibility.
- Maleimide group for selective thiol conjugation to cysteine residues.
- Propargyl (alkyne) handle for CuAAC click chemistry.
- Suitable for synthesis of antibody-drug conjugates and other bioconjugates.
- Supplied as a 10 mg package for research-scale use.
![eMolecules endo-BCN-PEG8-amine | Broadpharm |588.739 | C29H52N2O10 | 98.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC1[C@@H]2CCC#CCC[C@H]12 | 100mg | 795361837](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502472886.JPG-250.jpg)
eMolecules endo-BCN-PEG8-amine | Broadpharm |588.739 | C29H52N2O10 | 98.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC1[C@@H]2CCC#CCC[C@H]12 | 100mg | 795361837
endo-BCN-PEG8-amine | Broadpharm |588.739 | C29H52N2O10 | 98.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC1[C@@H]2CCC#CCC[C@H]12 | 100mg | 795361837
Medchemexpress LLC DSPE-PEG-maleimide (MW 3400) ammonium | 474922-22-0 | >95.0% | 3,400 Da | (C2H4O)nC52H93N3NaO13P | 50 MG
DSPE-PEG-maleimide (MW 3400) ammonium is a phospholipid-polyethylene glycol conjugate bearing a terminal maleimide reactive group. Supplied as the ammonium salt with a nominal PEG molecular weight of 3,400 Da, it is used to introduce thiol-reactive functionality into lipid assemblies for site-specific conjugation and formulation of PEGylated lipid nanoparticles and nanostructured lipid carriers.
- Provides maleimide functionality for thiol-specific conjugation.
- Anchors into lipid bilayers via DSPE for stable incorporation into liposomes and nanoparticles.
- PEG chain (3,400 Da) imparts steric stabilization and extended circulation.
- Compatible with thiol-containing ligands for targeted conjugation.
- Typically supplied at ≥95% purity; store under dry and low-temperature conditions.
Medchemexpress LLC Endo-BCN-PEG2-alcohol | 1807501-85-4 | 98.0% | 325.40 | 100 MG
endo-BCN-PEG2-alcohol is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring a BCN group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. PROTACs consist of two different ligands connected by a linker; one for an E3 ubiquitin ligase and the other for the target protein. PROTACs degrade target proteins using the intracellular ubiquitin-proteasome system.
- Purity: 98.0%
- Molecular weight: 325.40
- Formula: C17H27NO5
- Appearance: Oil
- Color: Colorless to light yellow
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: -20°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light)
Medchemexpress LLC Carboxy-PEG4-phosphonic acid | 1623791-69-4 | 96.0% | C11H23O9P | 50 MG
Carboxy-PEG4-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. It is for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
NCCOCCNC(=O)CCCCC(=O)N1Cc2ccccc2C#Cc2ccccc12)(OCC)OCC | 25mg | 627958419](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502480452.JPG-250.jpg)
eMolecules DBCO-PEG-Silane, MW 5,000 | Broadpharm |666.891 | C35H50N4O7Si | 0.000 | CCO[Si](CCCNC(=O)NCCOCCNC(=O)CCCCC(=O)N1Cc2ccccc2C#Cc2ccccc12)(OCC)OCC | 25mg | 627958419
DBCO-PEG-Silane, MW 5,000 | Broadpharm |666.891 | C35H50N4O7Si | 0.000 | CCO[Si](CCCNC(=O)NCCOCCNC(=O)CCCCC(=O)N1Cc2ccccc2C#Cc2ccccc12)(OCC)OCC | 25mg | 627958419
Medchemexpress LLC BODIPY FL alkyne | 1MG
BODIPY FL alkyne (BOD FL alkyne) is a green-fluorescent dye (Ex 503 nm Em 512 nm) a bright and photostable fluorophore which emits in fluorescein (FAM) channel BODIPY FL alkyne can be conjugated with a number of azide-containing molecules by copper-catalyzed Click Chemistry
Medchemexpress LLC Dope-peg-azide | 99.6% | 1000 (average) | 5 MG
DOPE-PEG-Azide (MW 1000) is a DOPE-based phospholipid functionalized with a polyethylene glycol (PEG) chain terminating in an azide group. The azide handle enables bioorthogonal click chemistry for conjugation and surface modification of liposomes, lipid nanoparticles, and other lipid-based formulations. The material is polydisperse with an average PEG molecular weight of 1000 and is supplied for research use.
- Provides azide functional group for copper-catalyzed or copper-free click chemistry.
- Average PEG molecular weight 1000 (polydisperse).
- High purity suitable for formulation and bioconjugation (purity listed as 99.62%).
- Suitable for liposome and lipid nanoparticle functionalization.
- Available in small pack sizes for screening and method development.
- Store at -20 °C in pure form.
Cayman Chemical ANTIBODY DBCO-amIn 250mg
A copper-free click chemistry reagent; has been used in the synthesis of clickable fluorescent probes
eMolecules 56282-36-1 | Thiol-PEG3-alcohol | Broadpharm | MFCD04116140 | 166.240 | C6H14O3S | 98.000 | OCCOCCOCCS | 1g | 138794132
Thiol-PEG3-alcohol | Broadpharm | 56282-36-1 | MFCD04116140 | 166.240 | C6H14O3S | 98.000 | OCCOCCOCCS | 1g | 138794132
eMolecules 1235514-18-7 | t-Boc-Aminooxy-PEG3-amine | Broadpharm | MFCD24471202 | 308.375 | C13H28N2O6 | 98.000 | CC(C)(C)OC(=O)NOCCOCCOCCOCCN | 500mg | 303671296
t-Boc-Aminooxy-PEG3-amine | Broadpharm | 1235514-18-7 | MFCD24471202 | 308.375 | C13H28N2O6 | 98.000 | CC(C)(C)OC(=O)NOCCOCCOCCOCCN | 500mg | 303671296
![eMolecules 642091-68-7 | t-Boc-N-Amido-PEG3-azide | Broadpharm | MFCD22056317 | 318.374 | C13H26N4O5 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCN=[N+]=[N-] | 500mg | 112541417](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC1681017.jpg-250.jpg)
eMolecules 642091-68-7 | t-Boc-N-Amido-PEG3-azide | Broadpharm | MFCD22056317 | 318.374 | C13H26N4O5 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCN=[N+]=[N-] | 500mg | 112541417
t-Boc-N-Amido-PEG3-azide | Broadpharm | 642091-68-7 | MFCD22056317 | 318.374 | C13H26N4O5 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCN=[N+]=[N-] | 500mg | 112541417